刘昌胜

                                      
刘昌胜     生物医学工程专业   硕士生导师
                        
材料学专业       博士生/硕士生导师    

1. 个人简介
刘昌胜,男,湖北大冶人,1967年出生于湖北省大冶县。博士、教授、博士生导师。教育部“长江学者计划”特聘教授;国家杰出青年基金获得者;国家重大科学研究计划首席科学家;“新世纪百千万人才工程”国家级人选;华东理工大学材料科学与工程学院院长
刘昌胜曾任国家自然科学基金委学科评委、国务院学位委员会第六届材料学科评议组成员。
1989年毕业于湖北大学生物学专业,获理学学士学位;1992年毕业于华东理工大学生物化工专业,获工学硕士学位;1996年毕业于华东理工大学化学工程专业,获工学博士学位。
1992年至1993年在华东理工大学生化工程学科,任助教;
1993年至1999年在华东理工大学技物所,历任助教、讲师、副教授、教授,研究室主任、副所长、党支部书记。
1999年至2008年华东理工大学材料科学与工程学院生物材料研究所所长,教授,博士生导师。
2001年至今教育部医用生物材料工程研究中心主任,其中,2005年3月至9月,美国University of Pennsylvania访问教授。
2009年至今华东理工大学材料科学与工程学院院长。
 
2. 主要社会兼职
中国生物材料学会 常务理事,兼青年委员会主任,纳米生物材料分会主任
中国生物医学工程学会生物材料分会 常务理事
中国生物医学工程学会组织工程与再生医学分会常务理事
中国复合材料学会 理事
上海市硅酸盐学会 副理事长
上海市生物医学工程学会生物材料专业委员会 副主任委员
上海市科技启明星联谊会 副理事长
无机材料学报 编委
中国修复重建外科杂志编委等
 
3.主要研究方向
        兼具材料、生物和化工的学术背景,主要从事生物材料的研究,包括组织修复与再生材料、纳米生物材料、可注射生物材料、药物/生物活性因子控释等。
 
4.主要业绩
        从事人体硬组织修复材料的研究和开发,以及纳米生物材料的研究工作。作为项目负责人,先后承担了国家“863”项目、国家自然科学基金重点及面上项目、国家重大科学研究计划项目等,将化学反应工程的原理和方法用于人体组织修复材料的可控制备及相关机理研究,开发出一种新型硬组织修复材料——自固化磷酸钙人工骨产品,并于2000年获得国家食品药品监督管理局的准生产注册证。该材料实现了形状任意可塑、人体内自行硬化和好的生物相容性的统一,并在体内诱导新骨形成,解决了长期以来困扰骨科医生和病人的骨缺损修复材料问题。新材料可广泛用于骨科、整形科、脑外科及口腔科等领域。经上海市科技情报所检索,未见与该成果相同的已获注册许可证的同类产品报道。该材料由多种磷酸钙盐组成,用自制的固化液,可调和成糊状,能根据骨缺损部位,任意塑形、充填,最终成份可转化为低结晶度的羟基磷灰石。材料经体外试验和体内长期植人试验,表明材料无毒,无致癌、致畸形活性,与有机体亲和性好,植入后不引起异物反应,具有可降解性,在软组织中无成骨活性,但在骨膜下能引导成骨生长。是生物相容性高、性能好的骨修复材料。各项性能指标达到甚至部分超过国外类似产品的水平。目前已在全国500余家医院广泛使用,取得了非常满意的修复效果。临床医生标明采用该材料进行基础和应用研究发表论文250余篇。
        为了进一步提高材料的成骨活性,适应大段骨缺损及再生能力弱的病人的治疗要求,他采用基因工程技术,在原核生物中成功表达出骨形态发生蛋白-2(rhBMP-2),一种促进成骨的活性生长因子。通过攻克重组菌株的发酵和蛋白纯化、精制等过程的系列关键技术,得到高纯度rhBMP-2产品,实现生产稳定,经国外机构检测证实成骨活性高。获美国、中国授权等专利授权。将rhBMP-2用于骨修复材料的活性化修饰,突破了生长因子活性维持和控释等关键难题,制备出具有高成骨活性的骨修复材料。临床研究病例显示出优良的治疗效果,可明显促进骨生成,加速骨愈合。这对大段骨缺损及骨再生能力弱患者的治疗具有重要意义。创新性地提出利用材料与生长因子的相互作用提高生长因子骨诱导活性的新思路,通过类肝素磺化壳聚糖等,能有效提高rhBMP-2诱导成骨分化的能力,并研究了其机理。
 
5.主要论文及荣誉
        科研成果在国内外杂志发表论文250余篇,其中SCI收录论文160余篇。申请发明专利50项,已获授权发明专利33项,包括美国授权专利3项。先后获得2003年度国家科技进步二等奖(第一完成人)、2014年度国家自然科学奖二等奖(第一完成人)等国家及省部级奖励7项。
        1996年入选上海市科技启明星;1998年获世界华人发明博览会金奖;1999年入选上海市科技启明星跟踪计划;2000年入选教育部跨世纪优秀人才;2001年获上海市优秀科技启明星;2004年获得国家杰出青年科学基金,第二届上海市青年科技英才;2006年入选“新世纪百千万人才工程”国家级人选,获国务院特殊津贴,中国发明创业奖;2007年获上海市十大科技精英,中国青年科技奖,何梁何利基金科技创新奖,教育部“长江学者计划”特聘教授;2010年获全国优秀科技工作者;2012年获上海市青年科技杰出贡献奖,国际生物材料科学与工程Fellow终身荣誉称号(International Fellow of Biomaterials Science and Engineering)。
 
代表性专著/国家精品视频公开课:    
1.  刘昌胜等著,硬组织修复材料与技术,科学出版社,2014年8月出版
2. 刘昌胜等著,纳米微囊型血液代用品,科学出版社,2014年6月出版
3. 刘昌胜主编,生物医学工程,华东理工大学出版社,2012年出版
4.  刘昌胜,生物医用材料,国家精品视频公开课(2013年),http://www.icourses.edu.cn/details/10251V001
 
代表性论文
1 .Jinyang Li, Xue Qu, Gregory F. Payne, Cheng Zhang, Yuxin Zhang, Jianbo Li, Jie Ren, Hua Hong, Changsheng Liu, Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery, Adv. Funct. Mater. 2015, DOI: 10.1002/adfm.201403636
2.Lingyan Cao, Jing Wang, Juan Hou, Wanli Xing, Changsheng Liu, Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2, Biomaterials, 2014, 35(2):684-698
3 .Lingyan Cao, Jerome A. Werkmeister, Jing Wang, Veronica Glattauer, Keith M. McLean*, Changsheng Liu*, Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles, Biomaterials, 2014,35(9): 2730-2742
4.Fan Yang, Jing Wang, Juan Hou, Han Guo, Changsheng Liu, Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2, Biomaterials, 2013, 34: 1514-1528
5.Jing Zhang, Huanjun Zhou, Kai Yang, Yuan Yuan*, Changsheng Liu*, RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration, Biomaterials, 2013, 34: 9381-9392
6.Jun Zhao, Gang Shen, Changsheng Liu, Shaoyi Wang, Wenjie Zhang, Xiaochen Zhang, Xiuli Zhang, Dongxia Ye, Jie Wei, Zhiyuan Zhang, Xinquan Jiang, Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds, Tissue Engineering Part A, 2012, 18(1-2): 185-197
7.Deliang Zeng, Lunguo Xia, Wenjie Zhang, Hui Huang, Bin Wei, Qingfeng Huang, Jie Wei, Changsheng Liu, Xinquan Jiang, Maxillary Sinus Floor Elevation Using a Tissue-Engineered Bone with Calcium-Magnesium Phosphate Cement and Bone Marrow Stromal Cells in Rabbits, Tissue Engineering Part A, 2012, 18(7-8): 870-882
8 .Derong Zou, Lian Guo, Jiayu Lu, Xiuli Zhang, Jie Wei, Changsheng Liu, Zhiyuan Zhang, Xinquan Jiang, Engineering of Bone Using Porous Calcium Phosphate Cement and Bone Marrow Stromal Cells for Maxillary Sinus Augmentation with Simultaneous Implant Placement in Goats, Tissue Engineering Part A, 2012, 18(13-14): 1464-1478
9 .Chenglong Dai, Han Guo, Jingxiong Lu, Jianlin Shi, Jie Wei, Changsheng Liu*, Osteogenic evaluation of calcium/magnesium-doped mesoporous silica scaffold with incorporation of rhBMP-2 by synchrotron radiation-based mCT, Biomaterials, 2011, 32: 8506-8517
10.Wenjie Dong , Yongsheng Li*, Dechao Niu , Zhi Ma , Jinlou Gu , Yi Chen , Wenru Zhao ,Xiaohang Liu , Changsheng Liu , and Jianlin Shi*, Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy, Adv. Mater. 2011, 23, 5392–5397
11.Qi Gan, Xunyu Lu, Yuan Yuan, Jiangchao Qian, Huanjun Zhou, Xun Lu, Jianlin Shi, Changsheng Liu*, A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica, Biomaterials, 2011, 32: 1932-1942.
12.Yuan Yuan, Changsheng Liu*, Jiangchao Qian, Jing Wang, Yuan Zhang, Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells, Biomaterials, 2010, 31:730-740.
13.Jie Wei, Junfeng Jia, FanWu, Shicheng Wei, Huanjun Zhou, Hongbo Zhang, Jung-Woog Shin, Changsheng Liu*, Hierarchically microporous/macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration, Biomaterials, 2010, 31:1260-1269.
14.Chenglong Dai, Changsheng Liu*, Jie Wei, Hua Hong, Qinghui Zhao, Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control, Biomaterials, 2010, 31:7620-7630.
15.Yan Sheng, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Fan Yang, Xiaoqian Shan, Huanjun Zhou, Feng Xu,Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials, 2009, 30: 2340-2348.
16.Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su, Changsheng Liu*, Preparation and characterization of bioactive mesoporous wollastonite – Polycaprolactone composite scaffold. Biomaterials, 2009,30:1080-1088.
17.Huanjun Zhou, Jiangchao Qian, Jing Wang, Wantong Yao, Changsheng Liu*, Jianguo Chen, Xuehua Cao,Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N,6-O-sulfated chitosan in vitro and in vivo,Biomaterials,2009,30:1715-1724.
18.Chenglong Dai, Yuan Yuan, Changsheng Liu*, Jie Wei, Hua Hong, Xiaosheng Li, Xiaohua Pan, Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control, Biomaterials, 2009, 30: 5364-5375.
19.Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Development of mussel adhesive polypeptide mimics coating for in-situ inducing re-endothelialization of intravascular stent devices, Biomaterials, 2009, 30 :2764-2773.
20.Jing Wang, Changsheng Liu*, Xin Lu, Min Yin, Copolypeptides of 3,4-Dihydroxypheny- lalanine and L-lysline to Mimic Marine Adhesive Protein, Biomaterials, 2007, 28:3456-3468.
21.Jian Zhao, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Xiaoqian Shan, Yan Sheng, Fan Wu, Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers, Biomaterials, 2007, 28:1414-1422.
22.Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Rheological Properties of Concentrated Aqueous Injectable Calcium Phosphate Cement Slurry, Biomaterials, 2006, 27: 5003-5013.
23. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Effects of the Granularity of Raw Materials on the Hydration and Hardening Process of Calcium Phosphate Cement, Biomaterials, 2003,24: 4103-4113.
24.Changsheng Liu*, Wei Gai, Songhua Pan, Zisheng Liu, The Exothermal Behavior in the Hydration Process of Calcium Phosphate Cement, Biomaterials, 2003, 24:2995- 3003.
25.Changsheng Liu*, Yue Huang, Jinhua Cui, Kinetics of Hydroxyapatite Precipitation at pH 10 to 11, Biomaterial, 2001, 22:301-306.
26.Jing Wang, Changsheng Liu*, Yufei Liu, Shuo Zhang, Double-Network Interpenetrating Bone Cement via in situ Hybridization Protocol, Advanced Functional Materials, 2010, 20: 3997-4011.
27.Xiaoqian Shan, Yuan Yuan, Changsheng Liu*, Feng Xu, Yan Sheng, Comparison of the PLA-mPEG and mPEG-PLA-mPEG copolymers nanoparticles on the plasma protein adsorption and in vivo biodistribution, Soft Matter, 2009, 5, 2875-2883
28.Changsheng Liu*, Wei Shen, Yanfang Gu, Mechanism of Hardening Process for a Hydroxyapatite Cement, J. Biomed. Mat. Res., 1997, 35(1): 75~80
29.Changsheng Liu*, Wengbo Wang, Wei Shen, Tongyi Chen, Yanfang Gu, Zhongwei Chen, Evaluation of the Biocompatibility of a Nonceramic Hydroxyapatite, J. Endodontics, 1997, 23(8), 490~493
30.Changsheng Liu*, Wei Shen, Effect of Crystal Seeding on the Hydration of Calcium Phosphate Cement, J. Mat. Sci: Mat. Med., 1997, 8(12): 803~807
31.Changsheng Liu*, Xingyan Wu, Optimization of Operation Parameters in Ultrafiltration Process, J. Biotech., 1998, 66(2-3):195~202
32.Changsheng Liu*, Wei Shen, Jianguo Chen, Solution Property of Calcium phosphate Cement Hardening Body, Mat. Chem. Phys., 1999, 58:78~82
33.Changsheng Liu*, Yue Huang, Haiyan Zheng, Study on the Hydration Process of Calcium Phosphate Cement by AC Impedance Spectroscopy, J. Am. Ceram. Soc., 1999, 82(4):1052-1057
34.Changsheng Liu*, Xingyan Wu, Determination of Membrane Area in the Ultrafiltration Process, J. Chem. Technol. Biotechnol., 2001,76(10):1023~1029
35.Changsheng Liu*, Yue Huang, Jianguo Chen, Haiyu Qi, The Physicochemical Properties of the Solidification of Calcium Phosphate Cement, J. Biomed. Mat. Res. Part B: Appl Biomater, 2004,69B: 73–78
36.Changsheng Liu*,Study on the synthesis and the biological properties of nanometer hydroxyapatite, J Dalian University,2004,25(2):42-44
37.Changsheng Liu*, Chien-Wen Chen and Paul Ducheyne,In vitro surface reaction layer formation and dissolution of calcium phosphate cement–bioactive glass composites,Biomed. Mater. 3 (2008)034111(11pp)  doi:10.1088/1748-6041/3/3/034111
38.Zhao Jian, Changsheng Liu*. Effect of the crystalline of matrix polymer on release profiles of hemoglobin-loaded nanoparticles. Tissue Engineering, 2006, 12 (4): 1097-1098.
39.Yuan Yuan, Changsheng Liu*, Yuan Zhang,Radio Frequency Plasma Polymers of n- Butyl Methacrylate and Their Drug-Controlled Release Characteristics. I. Effect of the oxygen gas,Surf. Coat. Technol.,2007,201(15):6861–6864
40.Jing Wang, Changsheng Liu*, Synthesis and properties of chitosan/polypeptide bioconjugate composite, Biomed. Mater., 2007, 2:32-38
41.Jing Wang, Changsheng Liu*, Ping Chi, Aggregate formation and surface activity of partially deacetylated water-soluble chitin, Research on Chemical Intermediates, 2008, 34(2–3), 169–179
42.Xiaolan Zhang, Changsheng Liu*, Yuan Yuan, Shiyu Zhang, Xiaoqian Shan, Yan Sheng, Feng Xu. Key parameters affecting the initial leaky effect of hemoglobin-loaded nanoparticles as blood substitutes. J Mater Sci: Mater Med, 2008, 19:2463–2470
43.Xiaolan Zhang, Changsheng Liu*, Yuan Yuan, Xiaoqian Shan, Yan Sheng, Feng Xu,Reduction and Suppression of Methemoglobin Loaded in the Polymeric Nanoparticles Intended for Blood Substitutes,J Biomed Mater Res Part B: Appl Biomater,2008,87B: 354–363
44.Jing Wang, Changsheng Liu*, Ping Chi. In Situ Preparation of Glycoconjugate Hollow Microspheres Mimetic the Extracellular Matrix via Interfacial Polymerization. International Journal of Biological Macromolecules 2008, 42:450-454
45.Yuan Yuan, Changsheng Liu*, Min Yin, Yuan Zhang. Plasma Deposition n- Butyl Methacrylate Coating with Potential for Stent Surface Modification. Journal of Materials Science:Material in Medicine, 2008, 19(5):2187-2196
46.Yuan Yuan, Changsheng Liu*, Yuan Zhang, Xiaoqian Shan, Sol–gel auto-combustion synthesis of hydroxyapatite nanotubes array in porous alumina template, Materials Chemistry and Physics, 2008, 112: 275–280
47.Xiaolan Zhang, Changsheng Liu*, Yuan Yuan, Xiaoqian Shan, Yan Sheng, Feng Xu. A Noninvasive Method for Measuring the Oxygen binding-releasing Capacity of Hemoglobin-loaded Polymeric Nanoparticles Used as Oxygen Carrier. J Mater Sci: Mater Med, 2009, 20: 1025–1030.
48.Xiaoqian Shan, Changsheng Liu*, Yuan Yuan, Feng Xu, Xinyi Tao, Yan Sheng, Huanjun Zhou. In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(ethylene-glycol)-modified PLA (BAB type) triblock copolymer. Colloids and Surface B-Biointerfaces, 2009, 72: 303–311
49.Jing Wang, Changsheng Liu*, Ping Chi. One-Step Preparation of Glycopeptide Microspheres Based on α-Amino Acid-N-carboxyanhydride Polymerization using Interfacial Protocols. Journal of Biomedical Materials Research: Part B, 2009,89B: 45-54   
50.Hua Hong, Changsheng Liu*, Wenjing Wu, Preparation and characterization of chitosan/PEG/gelatin composites for tissue engineering, J Appl Polym Sci, 2009, 114(2): 1220 - 1225
51.Yan Sheng, Changsheng Liu*, Yuan Yuan, Xiaolan Zhang, Xiaoqian Shan, Feng Xu, Porosity and Semipermeability of Hemoglobin-Loaded Polymeric Nanoparticles as Potential Blood Substitutes, J Biomed Mater Res Part B: Appl Biomater, 2009, 91B: 631–642
52 .Lihua Ma, Changsheng Liu*, Preparation of chitosan microspheres by ionotropic gelation under a high voltage electrostatic field for protein delivery. Colloids Surf. B: Biointerf. 2010, 75(2): 448-453
53.Fangping Chen, Changsheng Liu*, Yuhao Mao, Bismuth-doped injectable calcium phosphate cement with improved radiopacity and potent antimicrobial activity for root canal filling, ACTA Biomterialia, 2010, 6: 3199–3207
54.Fangping Chen, Changsheng Liu*, Jie Wei, Xiao Chen, Zhen Zhao, Yanli Gao,Preparation and characterization of injectable calcium phosphate cement paste modified by polyethylene glycol-6000,Materials Chemistry and Physics , 2011, 125: 818–824
55.Jiaping Lin, Suning Zhang, Tao Chen, Changsheng Liu, et al., Calcium phosphate cement reinforced by polypeptide copolymers, Journal of Biomedical Materials Research , Part B: Applied Biomaterials,2006, 76(2):432~439.
56.Han Guo, Jie Wei and Changsheng Liu*,Development of a degradable cement of calcium phosphate and calcium sulfate composite for bone reconstruction,Biomed. Mater. 2006,1:193–197
57.Hua Hong, Jie Wei, Changsheng Liu*,Development of asymmetric gradational-changed porous chitosan membrane for guided periodontal tissue regeneration,Composites: Part B ,2007, 38: 311-316
58.Han Guo, Jie Wei, Yuan Yuan, Changsheng Liu*, Development of Calcium Silicate /Calcium Phosphate Cement for Bone Regeneration, Biomed. Mater.,2007,2:S153–S159
59.Xiangqi Qin, Yuan Yuan, Changsheng Liu*, Qiuyun Wang, Xi Shen, Baican Yang, Preparation of Liposomal Brucine and Its Pharmaceutical/Pharmacodynamic Characterization, Acta Pharmacologica Sinica, 2007, 28(11):1851-1858
60.Ping Chi, Jing Wang, Changsheng Liu*,Synthesis and characterization of polycationic chitosan-graft-poly (l-lysine),Materials Letters, 2008, 62:147–150
61.Yuan Zhang, Yuan Yuan and Changsheng Liu*, Fluorescent Labeling of Nanometer Hydroxyapatite, J. Mater. Sci. Technol. , 2008, 24(2): 187-191
62. Han Guo, Jie Wei, Hang Kong, Changsheng Liu*, and Kefeng Pan, Biocompatibility and osteogenesis of calcium phosphate cement scaffolds for bone tissue engineering, Advanced Materials Research, 2008, 47-50: 1383-1386
63.Kai Wang, Christian Rüssel, Changsheng Liu*, Preparation, mechanical properties and erosion behaviors of oriented Ca(PO3)2 glass-ceramics, Materials Chemistry and Physics, 2008, 111:106–113
64.Fan Wu, Jie Wei, Han Guo, Changsheng Liu*, Self-setting Bioactive Calcium-Magnesium Phosphate Cement with High Strength and Degradability for Bone Regeneration, ACTA Biomaterialia, 2008, 4:1873–1884
65 .Fangping Chen, Kai Wang, Changsheng Liu*,Crystalline structure and its effects on the degradation of linear calcium polyphosphate bone substitute,Applied Surface Science, 2008,255:270–272
66.Kai Wang, Fangping Chen, Changsheng Liu*, Christian Rüssel, The effect of polymeric chain-like structure on the degradation and cellular biocompatibility of calcium polyphosphate, Materials Science and Engineering C, 2008, 28: 1572–1578
67. Fan Wu, Jiacan Su, Jie Wei, Han Guo,Changsheng Liu*,Injectable bioactive calcium–magnesium phosphate cement for bone regeneration,Biomed. Mater.,2008,3(4): 044105 (7pp) ,doi:10.1088/1748-6041/3/4/044105
68.Han Guo, Jiacan Su, Jie Wei, Hang Kong, Changsheng Liu*. Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering. Acta Biomaterialia, 2009, 5: 268–278
69.Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Combinatorial coating of adhesive polypeptide and anti-CD34 antibody for improved endothelial cell adhesion and proliferation, J Mater Sci: Mater Med , 2009, 20:1513–1523
70.Zhengli Xu, Jiao Sun, Changsheng Liu, Jie Wei,Effect of Hydroxyapatite Nanoparticles of Different Concentrations on Rat Osteoblast, Materials Science Forum, 2009, Vols. 610-613: 1364-1369
71.Yan Sheng, Yuan Yuan, Changsheng Liu*, Xinyi Tao, Xiaoqian Shan, Feng Xu, In vitro macrophage uptake and in vivo biodistribution of PLA–PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content, J Mater Sci: Mater Med , 2009, 20:1881–1891
72.Jie Wei, Xiaohui Wu, Changsheng Liu*, Junfeng Jia, Su-jin Heo, Seung-eon Kim, Yong-taek Hyun, Jung-Woog Shinw, Fabrication of Bioactive Scaffold of Poly(e-Caprolactone) and Nanofiber Wollastonite Composite, J. Am. Ceram. Soc., 2009, 92(5): 1017–1023
73.Feng Xu, Yuan Yuan, Xiaoqian Shan, Changsheng Liu*, Xinyi Tao, Yan Sheng, Huanjun Zhou, Long-circulation of hemoglobin-loaded polymeric nanoparticles as oxygen carriers with modulated surface charges, International Journal of Pharmaceutics, 2009, 377: 199–206
74.Junling Wang, Yuan Yuan, Changsheng Liu*, Di Zhu, Xi Shen, Baican Yang, Preparation and pharmaceutical/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel, J Mater Sci: Mater Med, 2009, 20:2075–2084
75.Xiaoqian Shan, Yuan Yuan, Changsheng Liu*, Xinyi Tao, Yan Sheng, Feng Xu, Influence of PEG chain on the complement activation suppression and longevity in vivo prolongation of the PCL biomedical nanoparticles, Biomed Microdevices, 2009, 11:1187–1194
76.Xiaohui Wu, Liang Ye, Kun Liu, Wei Wang, Jie Wei, Fangping Chen, Changsheng Liu*, Antibacterial properties of mesoporous copper-doped silica xerogels, Biomed. Mater. 4 (2009) 045008 (6pp), doi:10.1088/1748-6041/4/4/045008
77.Fangping Chen, Yuhao Mao, Changsheng Liu*, MG Yu. A novel silicate-doped calcium-based composite dental pulp capping agent. Asia-pacific J. Chemical Engineering, 2009, 4(5): 522-527
78 .Xiaoqian Shan, Ligen Chen, Yuan Yuan, Changsheng Liu*, Xiaolan Zhang, Yan Sheng, Feng Xu. Quantitative analysis of hemoglobin content in polymeric nanoparticles as blood substitutes using Fourier transform infrared spectroscopy. Journal of Materials Science: Materials in Medicine, 2010, 21:241–249
79.Lei Wang, Yuanliang Huang, Kefeng Pan, Xinquan Jiang, Changsheng Liu, Osteogenic Responses to Different Concentrations/Ratios of BMP-2 and bFGF in Bone Formation, Annals of Biomedical Engineering, 2010, 38(1): 77–87
80. Yonglin Yu, Jing Wang, Changsheng Liu*, Bingwen Zhang, Honghong Chen, Han Guo, Gaoren Zhong, Weidong Qu, Songhui Jiang, Huangyuan Huang, Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement, Colloids and Surfaces B: Biointerfaces, 2010, 76: 496–504
81.Guangping Xie, Jiao Sun, Gaoren Zhong, Changsheng Liu, Jie Wei, Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro, J Mater Sci: Mater Med, 2010, 21:1875–1880
82.Junfeng Jia, Huanjun Zhou, Jie Wei, Xin Jiang, Hong Hua, Fangping Chen, Shicheng Wei, Jung-Woog Shin, Changsheng Liu*, Development of magnesium calcium phosphate biocement for bone regeneration, J. R. Soc. Interface,2010,7(49): 1171-1180
83. Huanjun Zhou, Jie Wei, Xiaohui Wu, Jianlin Shi, Changsheng Liu*, Junfeng Jia, Chenglong Dai, Qi Gan, The bio-functional role of calcium in mesoporous silica xerogels on the responses of osteoblasts in vitro,J Mater Sci: Mater Med, 2010, 21:2175–2185
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