【Resume】

Jian-Jiang Zhong:Cheung Kong scholar Doctorial Supervisor Professor Winner of National Outstanding Youth Prize National Candidate of New Century Millions of Talents Program 

    Education:

BS (ECUST) 1986;  MS (Osaka U) 1990;  Ph.D. (Osaka U) 1993

 

Positions Held:

Lecturer, ECUST, Apr 1993; Assoc Professor, ECUST, Aug 1993; Professor, ECUST, Nov 1996

 

【Major research findings】

Professor Zhong together with his colleagues has proposed or modified bioreactors for plant cell cultures and mushroom fermentation, and successfully finished lab-scale reactor scale-up (e.g., Biotech Bioeng 51: 511; ibid. 51: 520, 1996; J Biosci Bioeng 92: 389, 2001; Biotechnol Prog 17: 838, 2001; Biotech Prog 17: 838, 2001; ibid. 20: 1076, 2004).

 

His group has reported a new two-stage cultivation methodology by combining aerobic fermentation with static cultivation, which efficiently enhanced the production of a valuable secondary metabolite – ganoderic acid (Biotech Prog 18: 51, 2002), and identified the key scale-up factors (Biotech Prog 19: 1842, 2003; Adv Biochem Eng Biotech 87, 2004).

 

Dr. Zhong and his collaborators have also innovated a couple of technologies/strategies for improving the production efficiency of bioprocesses, such as the combination of methyl jasmonate addition and sugar feeding (Biochem Eng J 8: 145, 2001; Enzyme Microb Tech 31: 116, 2002; Biochem Eng J, 12: 93, 2002), repeated elicitation and sugar feeding (Biotech Lett 24: 445, 2002), the use of newly synthesized jasmonates analogues as novel signaling molecules in plant cell cultures for taxoid production as well as related mechanism studies (Biotech Bioeng 86: 595; ibid. 86: 809, 2004; ibid. 90: 516, 2005). They have also applied pulsed electric field as a new type of abiotic elicitor in stimulating plant secondary metabolism (Biotech Bioeng, 88: 788, 2004), and developed SOUR(specific oxygen uptake rate)-monitoring-based substrate feeding strategy for both high-density cell cultivation and highly efficient production of bioactive ginsenosides and polysaccharides.

 

Professor Zhong has proposed the concept regarding rational manipulation of secondary metabolite heterogeneity in plant cell cultures (Plenary lecture, Proceedings of the APBioChEC, Phuket, Thailand, 1999; Adv Biochem Eng Biotech 100: 53, 2005), and his group has succeeded in the regulation of ginsenoside biosynthesis by applying jasmonates (J Biosci Bioeng, 93: 48, 2002), via calcium signaling and discovery of new enzymes (Biotech Bioeng, 89: 444, 2005; Process Biochem, 40: 3742, 2005), bioreactor operation (Appl Microbiol Biotech, 67: 752, 2005) as well as the application of new elicitors (Appl Microbiol Biotech, Online First, 2005). His group has also found the new biological activities of ganoderic acids and investigated their anti-tumor mechanisms. In his early work, Dr. Zhong reported the pseudo-plastic fluid of plant cell cultures, on-line monitoring of key bioprocess parameters, and the quantitative effects of shear stress, mixing, light irradiation and oxygen supply on cell growth and secondary metabolite production in plant cell cultures in bioreactors.

 

Professor Zhong has published 2 international books (Springer), 3 special issues of international journals, more than 120 international articles since 1991, and over 100 papers among them being cited by Science Citation Index (SCI), in addition to numerous papers in Chinese journals/books.

 

Dr. Zhong was awarded the Cheung Kong Scholar Professorship from the Ministry of Education of China (MOE, 1999), National Science Fund for Distinguished Young Scholars (NSFC, 2002), Young Asian Biotechnologist Prize (Society for Biotechnology, Japan, 2002), and the 1st-class Prize for Advancement of Science & Technology (MOE, 2004).

 

At present, he is on the editorial board of 10 international journals including Process Biochemistry (Elsevier), Editorial board (2002-Jan. 2005), Editor (Jan. 2005-); Biotechnology and Bioengineering (Wiley), Editorial board (2003-Aug. 2006), Associate Editor (Aug. 2006-); Biochemical Engineering Journal (Elsevier), Associate editor (2002-); Bioprocess and Biosystems Engineering (Springer), Associate editor (2005-); Enzyme and Microbial Technology (Elsevier), Editorial board (2002-); Journal of Bioscience and Bioengineering (Japan & Elsevier)Editorial board (2002-); Advances in Biochemical Engineering/Biotechnology (Springer) Editorial board (2002-); Engineering in Life Sciences(Wiley) Editorial board (2003-); Recent Patents on Biotechnology (Bentham Science) International advisory board (2007-); Pakistan Journal of Biotechnology (Pakistan) International advisory board (2004-).

 

【Representative papers】

1. Hu, W.W., Yao, H., Zhong, J.J. Improvement of Panax notoginseng cell culture for production of ginseng saponin and polysaccharide by high density cultivation in pneumatically agitated bioreactors. Biotechnology Progress, 17(5): 838-846, 2001.

2. Fang, Q.H., Zhong, J.J. Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum. Biotechnology Progress 18(1): 51-54, 2002.

3. Liu, H.J., Liu, D.H., Zhong, J.J. Novel fermentation strategy for enhancing glycerol production by Candida krusei. Biotechnology Progress, 19(5): 1615-1619, 2003.

4. Tang, Y.J., Zhong, J.J. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnology Progress, 19(6): 1842-1846, 2003.

5. Qian, Z.G., Zhao, Z.J., Tian, W.-H., Xu, Y.F., Zhong, J.J., Qian, X.H. Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis. Biotechnology and Bioengineering, 86(5): 595-599, 2004.

6. Qian, Z.G., Zhao, Z.J., Xu, Y.F, Qian, X.H., Zhong, J.J. Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism. Biotechnology and Bioengineering, 86(7): 809-816, 2004.

7. Zhang, Z.Y., Zhong, J.J. Scale-up of centrifugal impeller bioreactor for hyperproduction of ginseng saponin and polysaccharide by high-density cultivation of Panax notoginseng cells. Biotechnology Progress, 20(4): 1076-1081, 2004.

8. Ye, H., Huang, L.L., Chen, S.D., Zhong, J.J. Pulsed electric field stimulates plant secondary metabolism in suspension cultures of Taxus chinensis. Biotechnology and Bioengineering 88(6): 788-795, 2004.

9. Mao, X.B., Zhong, J.J. Hyperproduction of cordycepin by two-stage dissolved oxygen control in submerged cultivation of medicinal mushroom Cordyceps militaris in bioreactors. Biotechnology Progress, 20(5): 1408-1413, 2004.

10. Yue, C.J., Zhong, J.J. Impact of external calcium and calcium sensors on ginsenoside Rb1 biosynthesis by Panax notoginseng cells. Biotechnology and Bioengineering, 89(4): 444-452, 2005.

11. Wang, W., Zhang, Z.-Y., Zhong, J.-J. Enhancement of ginsenoside biosynthesis in high density cultivation of Panax notoginseng cells by various strategies of methyl jasmonate elicitation. Applied Microbiology and Biotechnology, 67(6): 752-758, 2005.

12. Qian, Z.G., Zhao, Z.J., Xu, Y.F., Qian, X.H., Zhong, J.J. A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism. Applied Microbiology and Biotechnology, 68(1): 98-103, 2005.

13. Qian, Z.G., Zhao, Z.J., Xu, Y.F., Qian, X.H., Zhong, J.J. Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed-batch cultivation of Taxus chinensis cells. Biotechnology and Bioengineering, 90(4): 516-521,2005.

14. Yue, C.J., Zhong, J.J. Purification and characterization of UDPG:ginsenoside Rd glucosyltransferase from suspended cells of Panax notoginseng. Process Biochemistry 40(12): 3742-3748, 2005.

15. Wang, W., Zhao, Z.J., Xu, Y.F., Qian, X.H., Zhong, J.J. Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate. Applied Microbiology and Biotechnology, 70(3): 298-307, 2006.

16. Qian, Z.G., Zhao, Z.J., Xu, Y.F., Qian, X.H., Zhong, J.J. Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites. Biotechnology Progress, 22(1): 331-333, 2006.

17. Hu, F.X., Huang, J.H., Xu, Y.X., Qian, X.H., Zhong, J.J. Responses of defense signals, biosynthetic gene transcription and taxoid biosynthesis to elicitation by a novel synthetic jasmonate in cell cultures of Taxus chinensis. Biotechnology and Bioengineering (in press), 2006.

18. Zhong, J.J., Yue, C.J. Plant Cells: Secondary Metabolite Heterogeneity and Its Manipulation. In: Advances in Biochemical Engineering/Biotechnology (vol. 100): Biotechnology for the Future, pp. 53-88, 2005.

19. Zhong, J.-J. (ed.) Advances in Biochemical Engineering/Biotechnology (Vol. 72): Plant Cells. Springer-Verlag, Heidelberg. Aug. 2001. ISBN 3-540-41849-0

20. Zhong, J.-J. (ed.) Advances in Biochemical Engineering/Biotechnology (Vol. 87): Biomanufacturing. Springer-Verlag, Heidelberg. March 2004. ISBN: 3-540-20501-2

 

【Research Interests】

Applied biotechnology, Industrial biotechnology; Biochemical engineering, Bioprocess engineering, Bioreaction/bioreactor engineering; Fermentation technology

Environmental biotechnology; Plant cell culture; Signal transduction; Anti-tumor mechanism & Apoptosis; Bioprocess monitoring, modeling and control; Metabolic engineering and molecular bioengineering; Heterogeneity engineering of natural bioactive compounds

 

【contact】

Phone number：+86-21-64253823

Email：jjzhong@ecust.edu.cn