Nature Biomedical Engineering Publishes ECUST Breakthrough in Ultrasensitive Molecular Probe Dynamic Imaging

Recently, the top international academic journal in biomedical engineering, Nature Biomedical Engineering, published online a significant breakthrough by the research team of Academician Zhu Weihong and Professor Guo Zhiqian from the Photosensitive Products Research Center, School of Chemistry and Molecular Engineering, ECUST. The paper, titled “Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes” focuses on ultrasensitive molecular probes for imaging amyloid-β (Aβ) plaques in the brain.

This research was primarily conducted by Dai Jianfeng (Ph.D. candidate graduated in 2024, now at Zhonglan Chenguang Chemical Research and Design Institute Co., Ltd.) under the guidance of Associate Professor Yan Chenxu and Professor Guo Zhiqian, with careful supervision from Academicians Zhu Weihong and Tian He. Researchers Wei Weijun and Director Liu Jianjun from the Department of Nuclear Medicine, Renji Hospital, and Associate Researcher Ji Dingkun from the Molecular Medicine Institute also provided substantial support. The work received funding from several sources, including the Frontier Science Center for Materials Biology and Dynamic Chemistry (Ministry of Education), the Feringa Nobel Prize Scientist Joint Research Center, the National Science Fund for Distinguished Young Scholars, and the National Key R&D Program.